I think this should answer your questions:
According to Naughty Dog's creative director Amy Hennig, the theme of deception plays out in multiple ways throughout the threequel, from Drake doing the deceiving to Drake being deceived to some mysterious deception about Drake's very identity. The story focuses on the hero's relationship with his mentor and father figure, fan fave Victor "Sully" Sullivan, and has him searching for a legendary lost city that will ultimately take him to the Arabian Peninsula and the vast wasteland of the Rub' al Khali Desert, also known as the Empty Quarter.
Entertainment Weekly
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