If you consider the creatures that are created in the arena in FFX, then Nemesis hands down! But if you are talking about bosses in general, then Bizarro Sephiroth (only if you are able to get the three party system when you go to fight him and you hope that the party that wins is your pwered up party), followed by the final form of Ultimecia, and lastly Omega from FFV because he was the only thing I couldn't beat (that and Shinryu). Kefka earns an honorable mention because I couldn't remember the order when you have to choose your party and I invariably picked the weakest first.
Cheers!
Jessica
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