The Last of Us will be more of showing the relationships and moralities of humans under apocalyptic world rather than just blowing the zombies' heads off with shotgun like some other games. I think The Last of Us will be featuring humans much more than mutants.
And to be honest, I didn't even get to finish Fallout 3 or Las Vegas because those games were too boring to me. Not much of interesting stories and all I remember is fast travel, fast travel, companion, kill, kill, loot, fast travel, kill, unmemorable characters, unmemorable quests.
The typical moment I hate so much in the game is that the main character usually slaughter every single people in the game but when it comes to dealing with their boss, the main guy suddenly says something like "I'm not like you, I'm no murderer." and decides to show the bad guy some "mercy", only to ends up getting shot in the back.
I don't really think Uncharted series was great. It's pretty linear, short, and always end up weird at the end by suddenly showing weird monsters or zombie-like creatures that don't really make much of sense in Uncharted world. (The Last of Us is clearly staged as an apocalyptic world filled with mutants and insane humans, but Uncharted starts as a seemingly normal world with some ancient treasures to be found, and then shows us absurd monsters out of nowhere in later stage of the game.)
I wish The Last of Us is way awesome than those series.
KiPac's comments