I think an Assassins Creed set in South America would be pretty different from the previous titles.
My preferred time period would be during the spanish american wars of independence where the people of S. America fought for independence against the Spanish rulers.
According to Wikipedia the wars took place in the early 19th century.
South America has jungles, mountain ranges etc, just many varied environments so I think it could be cool.
KodiakKoolaid's comments