I think this moment will come at a later time and will involve the higher level of interactivity that motion sensor technology, like Kinect, offers. I know that's something the "hardcore" gamer crowd doesn't want to hear right now, but interactivity is what gives this industry it's edge, and the motion sensing technology will bring that interactivity to a higher level. It just needs to be developed more and needs the right amount of investment from a talented designer/artist. I'm not saying the technology needs to be at the point of "virtual reality" in order to create this seminal moment, but rather to be at a level where a highly interactive experience that allows for real emotions to be felt and expressed and also be functional and believable can be created. There are other technologies that can help bring this experience to a higher sensory level. 3D displays for instance. I think that it will take an embracing and melding of such technologies in order to foster this experience and help create this pivotal moment in gaming history.
I'm going with Marko on this one. Though I think it will be from the perspective of an illegal alien from Mexico. All the drug warfare and controversy surrounding the immigration issue would be too much for Rockstar to resist, and they have some good experience with southwest locales (Red Dead). My guess is the main protagonist will be a young guy who sneaks across the border with an older cousin/other family member, somehow ends up getting involved in the drug trade, joins a gang and does a bunch of illegal crap in order to earn money that he needs to send back to his elderly mother and father in Mexico. Bank on it.
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