The definitive RE4 experience is playing Wii Edition on Dolphin with mods.
Ultimate HD Edition improved the textures and added a 60fps option, but it was a downgrade in most other ways, lacking the specular lighting and DoF effects of the GameCube & Wii versions and lacking the Wiimote support of the Wii Edition, while the HD textures are uneven and the 60fps mode is poorly optimized. The problem with the Ultimate HD Edition is that it used the inferior PS2 version as a base, instead of using the superior GameCube and Wii versions as a base.
Playing Wii Edition on Dolphin with mods gives the best of both worlds, combining the specular lighting, DoF effects and Wiimote support of the Wii Edition along with higher-quality HD textures than the Ultimate HD Edition. Also, it plays best with the Wiimote, which improves the accuracy and gameplay.
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