Both are great, but you will probably play Puzzle League more.

User Rating: 9.9 | Dr. Mario & Panel de Pon GBA
Puzzle League is an addicting game that was on SNES as a Mario game. Your Mario characters sat on the side while you switched blocks and threw garbage at your opponent. However, sometimes Yoshi got in the way, and that was that.

Then it came out on N64 as a Pokemon game. You had to win your way through all the gym leaders, and then Gary, and, if you were good, you got 1 chance to beat Mewtwo.

This time, you choose the graphics, logos, music, and the rules as well. Making it much more than anyone expexcted. Pay a visit to the options menu when you buy it, because the default isn't very good.

Dr. Mario is similar in a way, yet there is less to customize as you play the old game in basically the same way. The only difference is that they have a new music called "Sneeze."

Puzzle League has definitely advanced, Dr. Mario not as much, but that doesn't stop it from being fun.