@Ghosthunter54 EA owns exclusivity rights to football so if 2k made a football game it would have to have no ties at all to NFL or NCAA. There is no exclusivity license for the NHL currently but NHL 2k has been beaten by EA's NHL series year in and year out. The opposite is true with basketball with EA pulling out after NBA 2k series is far more advanced and popular than EA's series.

I gotta say Vegas, or rather Las Venturas. It could still be set in the 60s and 70s when Vegas was still forming and there was a lot of criminal influences in the shaping of it. Plus the little "hint" they gave us, the V looking as if it was lifted off a dollar bill. Vegas is Sin City, the place of money. Sure they did Venturas before, but Liberty City got a major facelift and became a more living breathing city that to do the same to Venturas would be amazing.