Yes. Mgs2 Vamp on extreme/Euro extreme is highly frustrating if played how you're "supposed to." Hang off of a ledge and bust out a high damage close quarters weapon like the Nikita.
"Cheesing" bosses in devil may cry 1 is absolutely essential to getting a "Special Bonus" (S rank plus S, or SS in later games) ranking in some stages, super nero angelo comes to mind. It's still difficult to pull off.
The scale of AI manipulation varies in how much you "cheese" a particular part in a game as well. Using firestorm to kill every boss in demon's souls is partially just a survival tactic for example, whereas exploiting Vamp's behavior trivializes the encounter.