A lot of people don't seem to know that PhysX can be run on your processor even if you own an AMD card. In the case of Borderlands 2 the AMD cards run extremely well with and without PhysX enabled.
"With PhysX set to high, the GTX 680 became 19% slower at 1920x1200, averaging just 60fps instead of 74fps. Surprisingly, the HD 7970 did slightly better dropping 15% from 72fps to 61fps, and as far as we could tell, the PhysX effects looked identical on both brand of cards."
http://www.techspot.com/review/577-borderlands-2-performance/page5.html
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