Great gameplay, ridiculous storyline!
The game is great, having signed it's presence in other consoles as well - such as the Wii - but as far as my opinion goes, this gameplay on this one is the best on the series - the stylus really makes you feel like you're actually doing something, poking here and there, cutting flesh and using the correct instruments... it's just plain art.
The story however, is really, really weird. It starts decently, you, as a talented doctor, learning with the experiences of "real" life. After the game picks up the pace, however, you are immersed into a almost-alien-like atmosphere where you have to fight diseases virtually unexplainable. It's just weird. Flesh-cutting-fish-like-parasites, thorn-gas-expelling-triangulated-patterns, giant-bubbly-thingies... Seriously? I'd liked it better when my real occupation was a doctor - removing glass surgically was much more viable than... well, playing alien vs doctor.
The game has some kind of issues with the difficulty as well. There are operations that make you go smoothly, taking your reflexes at a decent pace, and everything... but sometimes, all of sudden, the game gets ridiculously hard, expecting almost unnaturally superhuman reflexes - and I'm not talking about the main character super powers.
If you can, somehow, forget about this two problems - difficulty and a strange story - you're in for a good game.
Expect some sweaty moments, though.