Possibly the best game of its kind since D2
For starters the landscapes are quite beautiful especially coastal regions and character models are pretty detailed and the only thing I can criticize about the graphics is that even on all high settings the shadows of some things come in a little funky.
The biggest hint of what the story is about will be in the cinematic so don't worry if you don't get the story in your first few hours of play. Once you do start playing, even if you don't know the story, you are hooked from the very first creature you kill.
There is some sound issues but nothing that takes away from the game.
The initial character creation is rather generic and may feel half baked at first but as you play on you'll see how the game wasn't focused on having a pre-determined class for your character. The skill system for each "class" is rather deep too.
Overall Titan Quest is a great game that is definitely worth picking up whether you're a hardened D2 veteran or new to the sub-genre