To continue on about this, tying the game into the original bioshock;
The game established the idea of "constants and viariables" comparing the two you get the obvious BookerComstock and Jack/Ryan as the "variables" to the "constant".
There also are the protectors (songbird and big daddies) both protecting a girl or girls. From here on out is merely my speculation, but Elizibeth seemed to know about rapture before teleporting booker and herself there. She stated that as a LITTLE GIRL she was able to go to other places. Is it possible that she went to rapture as a girl and in the world(s) of rapture she was captured and cloned/mutiliated into little sisters? In the world of rapture cloning was possible and it seems almost purpsefully done that the clothing and hair of Elizibeth and the little sisters are nearly identical.
The only details that might clarify my elizibeth/little sister idea is the knowledge of how vigors came to be and if Elizibeth had anything to do with it (and if so, Ryan could have utilized that same part). I'm hoping some DLC will delve into this to clarify.
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