I don't know... When talking about games that everyone MUST play, they first have to be games that everyone CAN play. On that note, only Super Mario Galaxy (a Wii game everyone Wii owner should play, if not have), Mario Kart Wii, and maybe Super Smash Bros. Brawl fits that bill. Even so, it's hard to go wrong with the Metroid Prime 3s and Resident Evil 4s of the world, if they are games of genres to your liking. Twilight Princess and Okami aren't bad choices for those looking for longer adventures. You also have to consider games like Zack&Wiki for what they bring to the table, and let's not consider some of the older great Wii games, like Super Paper Mario and Fire Emblem: Radiant Dawn.
Long story short, I see a "Big Three" in SMG, SSBB, and MKWii and a long list of other games that are worth trying, depending on tastes.
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