Loss of which franchise & company would dissapoint you most?

If a franchise/series could no longer be created for some reason, the loss of which one would most dissapoint you? How about for a game company, which would you be most upset to see die out? I'll have to think about this question some more before I answer it myself.

Well Clover Studios is already closed down... which is a loss... would love to see the Okami franchise continue...