It's either this, Kirby Canvas Curse, or Yoshi for your all-stylus gaming needs, and I have to say this is my fave.

User Rating: 8.8 | Chou Shittou Caduceus DS
Trauma Center: Under the Knife is really an excellent game which is controlled using the stylus only. The whole game is based on a story about GUILT, a form of medical terrorism and a doctor and his quest to eradicate GUILT. The story isn't that amazing, but it keeps you going. On to the bulk of the review:

Gameplay: 9
The gameplay is very very good. Y ou're constantly switching back and forth between tools to fix up your patient, and it becomes very very hectic once you get past the few beginning levels. There are many things you do in the game; it always switches objectives between missions, all of which are unique keeping gameplay fresh. It's highly addictive, and even though in the endgame levels, you're bound to lose some missions more than a few times, you'll just wanna keep on replaying it because its so fun. The controls are near perfect, except for the zoom function, which you have to draw a circle to zoom in with. Problem is, you have to draw a PERFECT circle. However,I found a way around this by just drawing "C"(it worked), but I don't think other people will.

Graphics:8
Well, theres not much in terms of graphics. In between missions, you have the story parts, which have some text and still shots of a backround and unanimated anime-ish characters, which actually look very good. During the mission, the organs are usually shown with some simplistic but nice 3D, and all the different effects are all in 2d, and look pretty nice.

Sound:8
Well, the sound effects are all excellent, and spot on, i guess. There are very few music tracks, but the ones that ARE there are very very good.

Value:7
This was my major problem with the game. THe game is only 6 hrs long(including how many times you will restart hard missions) and you can play a challenge mode to try to get better ranks on the missions(ranging from A,B,C) but you're bound to get bored before you manage to get A on everything.

Overall, this is a really really good game. The only problems really are the value, and the difficulty which some people will dislike, but I loved(always like a good challenge.) Yes, there are better DS games out there, but if you want a game that really uses the stylus well than IMO this is the best choice.