Laugh out loud point-and-click fun.
The puzzles aren't that fiendish, but as we're relative P&C newbies that's no disappointment. The sheer joy of this game is the dialogue - some of it really is laugh out loud funny, with some nice lines in satire and general mickey-taking.
Others have mentioned the feel of watching a Sit-Com, and it has to be said that some of the dialogue interactions really do have that feel to it, and it all hangs together quite nicely.
Voice acting is spot-on, and some of the songs crack me up (little buddy). The special agents singing about War being good was a belter - music and animation both containing belly-laughs.
And as for Reality 1.0... I let a bit of wee out, I was laughing so much. :-)
The biggest bug-bear is the occasional tendency to clip off the final few frames of audio from a soundbyte which can be a bit irritating, but you can always trigger the thing again if you think you've missed something important (usually the punchline to a joke).
We are midway through the last of the six episodes as I write, and I know I am really going to miss my time in Sam & Max's weird, wonderful and sublimely entertaining world. I do hope there's a sequel on the cards.
(EDIT: And I've just learned there will be - YAY!!)
More fun pointy-clicky-Wii things, please.