Dead Space 4 is almost guaranteed. Whether or not Issac is still the main character is up for debate. Killing off the main character is pretty common at the end of the trilogy (AC, ME, MW), and the events leading up to it pointed to it being Isaac's end as well. There were some good theories about his voice was at the end being Ellie's hallucinating, but I doubt Isaac will be in DS4. It's also possible that they're doing the same thing Mass Effect did at the end of their trillogy; killing off the protagonist without really commiting to it. If anyone has played it, you'll remember Shepard dying, a long scene about the after effects of his death, and at the last 3 seconds a pan over of Shepard's charred husk taking half a breath. I think Isaac is meant to be dead, but they added the last voice clip as a sort of cop out if for some reason they decide to include Isaac again.
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