Should PC gamers wait for the inevitable PC version? yes. Does the game have some core gameplay issues? yes.
Mass Effect has a great sci-fi story that unfolds over time, some great alien races, and the overall look and atmosphere is a 10 out of 10. Unfortunately there are aspects of the core gameplay that are frankly mediocre. The planet-side missions using the "Mako" vehicle should have never seen the light of day. The planets one visits are largely featureless, except for the craggy mountains that appear on every planet. The controls and camera viewpoint on the vehicle will annoy you and then there's the "thrasher" sandworm creature that can appear at anytime and "instakill" you. This whole aspect of the game needs a major overhaul. Sure you can grimace while you try to steer the Mako over a mountaintop and it wont go any further because only at that point does the game decide the mountain is too steep, but is any of this actually fun? No. There were several points in the game when I was dreading having to drive the Mako.
One of the things most game reviewers dont mention but irked me when I played is that one cannot completely control your team-mates during combat, as one could with Knights of the Republic. You can try to tell them where to stand but that doesnt work very well in practice. So they tend to die alot or get in your way. KOTOR really had a better combat interface. It doesnt help matters that the AI for both your team and the enemy needs a major patch. As it is, the AI all around is mostly braindead. For folks like myself who like the tactical challenge of combat, Mass Effect really stumbles in this regard.
If it werent for the superior look and generally great story-telling of Mass Effect, the game would get a 7 from me. However because of the great cinematic presentation, the game gets an 8.5. Sorry BioWare, but I'm not so sure I'll be pre-buying the sequel.