Very familiar start. Other than that, new ideas of surgery keep you feeling like a real doctor.
Stigma is a very familiar virus, as you'll notice, but it has many twists. When I first started this game and saw the first Stigma, I went, "Oh great.. I think I just bought the same game," because the beginning was all too familiar. BUT, it wasn't the same. I went through the first strand and found out that the little twist is that the virus could combine with each other and make 6x as many cuts as it would've done if it were by itself. Being cocky, I accidentally killed the patient the first time I was doing this stage since I thought I already knew what was going to happen.
New Blood offers new surgeries such as Brain Surgery and 3rd degree burned patients and it gets you back to the days of learning on what to do (If you've played previous Trauma Centers) If you haven't played any previous Trauma Centers, then this game will be a great puzzle to you, but in the good way. Sure, you will probably kill a couple people, but, in a weird maniacal way, it's fun! You learn new things every surgery and you progress more dexterity and accuracy as you improve your skills through the game, just like a real doctor! (Kind of)
Graphics in this game are great, exactly like the Second Opinion.
Music is great too, much like Second Opinion, but it has a good twist in the sounds that keep it fresh.
Difficulty shouldn't be too much of an issue in this game because you can change difficulty at any time. But otherwise, it's pretty hard mainly because it's aimed towards people at least 13 years of age. It would be really hard to play this game if you were a toddler or child and I wouldn't recommend it for them because they probably wouldn't like it anyways.
To justify why I didn't give it a 10 was because of it's extremely long story line. I seriously think that anywhere from 1/4 to 1/2 of your game time would be from reading/listening to the story line if you didn't skip it. I also didn't like the familiar beginning. It actually bored me since I've done those procedures so many times.
Oh, the Co-Op. The Co-Op in this game is great! I have not been able to experiment much with Co-Op, but I did one surgery with it and it makes the game much more fun. Having a friend beside you playing doctor makes the purchase of this game worthwhile.. unless you have horrible friends where all they would do is get the scalpel and just kill the guy. That would suck.
Overall, this is a great game and I think you should definitely go buy it. However, if you aren't into puzzles and don't have patience, then this might not be the game for you.