I think that it is possible. The sneaky sniper part should be pretty easy as long as you raise your sneak and guns levels. The perk that you must get is the sniper perk which increases the chances of getting a headshot. You will also want stealth armor like Chinese Stealth armor or Stealth Armor MK 2. The Silent Running Perk would also help. For the unarmed part it can be more difficult. In addition to raise your unarmed level you would also need good unarmed weapons like the powerfist, zap glove, or saturnite powerfist. You would also need a strong armor, since you will be in close quarters combat. Also there are unarmed perks like paralyzing palm that you may want to get. There are also some unarmed moves that some NPCs can teach you like Ranger Andy, Veronica, and the Great Khans.
Your indicator does not really help with this part of the quest. Look inside the desks and around the crates for anything that has the name NCR in front of it like NCR radio parts and NCR submachine gun.
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