I completed it with keyboard/mouse without any issues. Unless you count the glitches (found around 3 total game freezing glitches + a few which were manageable and didn't really hurt on my first run). It's all a matter of preference. I myself hate the X360 controller with a passion for some odd reason. Though some parts which require you to mash a button would propably be easier on a controller, but it's not that big of a deal.

@Flame_Devil999:

There is no way to do so, I'm afraid. Was thinking about it as well while playing.