Dude... clean your disc. I had EXACtly the same problem. Looked at disc and had smudge on it. Wiped it and game has been fine ever since. I think the PS3 can't load the data and just gets locked in a never ending cycle. GIve the disc a wipe even if it looks clean. Worked for me and some others have had same issue.thetruespin
DUDE!, I just bought the game 3 days ago and have never touched the disk other than taking it out of the case to insert into the PS3. I then took it back out when I ran into this problem on chapter 23 (to test and make sure it wasn't my PS3 that was the problem). There were no smudges and yes, that is one of the things I first thought of.
Miraculously it finally worked when I attempted to play the chapter again in the chapter select instead of "resume game". (I just had to start chapter 23 again for the THIRD time, which is a little irritating). I guess that I originally had a corrupt game save. Now I'm on chapter 25 so we shall see if it's smooth sailing the rest of the way. I did find a few other people on other websites that had the same issue ON CHAPTER 23 (and 24), so I'm guessing something is going wrong to corrupt certain people's loadfiles. It obviously is not a widespread problem, but searching the net it seems like the idential thing has happened to a few others and it seems to happen late in the game.