Activision released eight additional downloadable characters on the Xbox 360 via the Xbox Live Marketplace on April 26, 2007 in a set of packs: a Hero Pack, consisting of Cyclops, Nightcrawler, Hawkeye, and the Hulk, and a Villain Pack, which includes Magneto, Sabretooth, Venom, and a playable Doctor Doom, for 500 Microsoft Points (MSP) each. Both packs are also available in a bundle pack for 800 MSP, which also adds 12 new achievements to the game. The Gold Edition was released for the Xbox 360 in May 2007 which includes the standard game bundled with all downloadable content. The Platinum Hits version was released for the Xbox 360 in September 2007. The set includes all the Gold Edition of the game and a bonus DVD. As of December 2009, the DLC was removed from the Xbox LIVE Marketplace by Activision, meaning the only way to play as the downloadable characters is to purchase the Gold Edition or the Platinum Hits version.
The Wii version has a few features unique to its version including specific motion-sensitive controls for normal moves, motion-sensitive controlled special attacks (the attacks are unique for each character, but not the motions), and access to any special move at any time. This version contains no online play but has a local multiplayer mode in which up to four players may play at once. It also features the characters Colossus and Moon Knight, as well as five additional comic book missions.
The PC version is customizable, and many characters (including those exclusive to all other versions) and their modifications can be obtained from community sites for play within the game. The PC version's graphics vary depending on the customization of a user's settings. The PC version also features "intuitive mouse controls"  and works with a gamepad. A number of custom characters (including Jean Grey, Emma Frost, War Machine, and Punisher) are available.
The PSP version features simplified graphics, different characters, and extra features including the four exclusive playable Marvel characters Black Widow, Captain Marvel, Hawkeye, and Ronin. Other things unique to this version are 6 exclusive comic book missions including one which contains Swordsman, an exclusive prequel mission, and three exclusive single-player gameplay modes. Added features include online play, microphone support (voice chat), and online-recordable player statistics. The PlayStation 2 version of the game has the same features as the next-gen versions of the game, albeit without Colossus, Moon Knight and the five bonus simulator missions. In August 2007, a Greatest Hits version was released which included a bonus DVD containing a making-of featurette. The Xbox version of the game has no changes from the standard PlayStation 2 edition, however, a community-based modification has been released which adds Gambit, Hulk, Iron Fist, Moon Knight, and War Machine (Iron Man's third outfit being replaced by another costume) to the game. However it is possible to play as Colossus and Moon Knight via a glitch which can be accessed through a series of steps.[