GTA: San Andreas is definitley the best game in the series.
The gameplay is just fantastic. The thing that makes San Andreas good is the simple gameplay...or just shooting random people on the streets. This has everything, guns, cars and the new system in which you can increase your percentage in different categories, such as, fat, muscle, and even skill meter in driving the car. This game just goes so in depth that it's like living a regular day. The missions alone are simply amazing for the game. You really have fun doing these missions. I think Rockstar have executed perfectly and have made a fun game to play.
The graphics are good also. But there are at time where you'll think these graphics suck, especially in cut scenes. Usually when people are talking, they might show someones hands REAL up close. The thing that annoys me that why cant they make better hands! They look like one giant hand with no fingers. But thats such a small part of the game and doesnt really have an affect for the overall value.
The sound is good also. For voice acting this game is perfect for it. Even some of well known celebrities came and lent their voices for San Andreas such as Samuel L. Jackson (Officer Tenpenny), The Game (B-Dup), and Ice-T (Madd Dogg). I guess the reason for this is that their voices really suit the theme GTA: San Andreas. The soundtrack for this is amazing as well because it has one of the most popular songs on the San Andreas soundtrack.
All in all Rockstar has put together another great GTA game and i am really eager to get the next one for the PS3...that is if i get a PS3.