Title pretty much says it all.
Mine would have to be The Last of Us. That game looks excellent. Other than that, I'm looking forward to GoW: Ascension, Gears of War, BioShock, Crysis and Beyond: Two Souls.
And yes, I know I didn't inclue a lot of significant games, but I only get to list 5 choices. So just vote for Other and leave a reply behind if your most anticipated 2013 title isn't in the poll.
EDIT: F*ck me, how did I not include GTA 5 :|