well the ending of infamous left a few open ends:
[spoiler] -Sasha and Alden are still alive,
-Moya is blaming the situation on Cole,
-the beast that Kessler spoke of is coming (from the picture in the game, it appears to be a pyrokinetic, which could mean that something similar to the ray shpere was used, but it gave the beast power over flame rather than electricity) [/spoiler]
so would you like to see a sequal?