Quick question about controls etc.

Hey people!

I just bought a Ps3 on the internet and I should get my hands on it this weekend. I have never owned a console before, but I've played all the games you can possibly play on the Geforce 6100 (ew, I know), and I was wondering if it will be too hard for me to get used to the controls, and generally how big is the difference between the two platforms.

Thank you for your help!