The answer is no. I've tested. RAM makes no difference, as long as the program doesn't start to run out. Once you get pretty close though, either the garbage collector will go on overdrive (sometimes for ALL applications), causing worse performance, or C++ programs will start crashing. But unless you're REALLY close, it's not something to worry about. Also, you should be idling at no more than 2 gigs if you run windows 8 and anything more is abnormal, and have a standard set of background and foreground programs open.
@JigglyWiggly_: I used to go for times of multiple MONTHS (record 4 months) without turning off my computer or any restarts, and had all sorts of background stuff installed (I am a programmer and I end up with tons of background programs open from testing things, as well as various software I tried and didn't get rid of yet) and never even get near that with tons of programs open. Press control + alt + delete, and go to more details, and press "ram" and see WTF is taking that all. That's the kind of activity you might see from malware.
(And I actually currently run Ubuntu Linux on dual boot with windows, and normally run windows, but I'm saying that from when I used windows only)
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