So I just finished watching The Devil's Backbone which contains, for me anyway, one of the most horribly evil villains in film history. As an avid gamer, this made me think about any villains that have come close to matching the kind of contempt that movie villains can invoke in the viewer - particularly these days as games become more scripted and SP titles create more and more imaginative big bads.
I actually had a lot of trouble thinking of one that I truly hated. The vast majority of villains in games that I've played either don't measure up in their nastiness because they're either too complex, like the monstrous yet sympathetic Glados - or they're completely one dimensional and are simply there to be beaten. Like very Mario villain ever made.
I think the most disturbing kind of villain in both games and movies is actually the one that you end up identifying with. Someone who has such a twisted sense of logic and idealism that you start to find yourself agreeing with them because they're not ideas you would normally confront or consider. So they end up having a revelatory power which, if handled well, can be downright chilling.
So on that basis I have to cite BioShock's Andrew Ryan and Alma herself as my own choices because they both represent a sort of mirror for my own view of life and the world in general. As someone who often finds it difficult to embrace certain aspects of culture which often leads to conflict with those around me, Andrew Ryan's desire to retreat from society entirely and Alma bringing ruin to the world she perceives as having wronged her, both represent supressed aspects of my own psyche - aspects that can never be awoken or acted upon because they're unacceptable in the real world. Thus making them truly disturbing characters representative of my worst flaws.