My Gamersgate version is fine, so I'm not sure what the problem is. Still, I read this advice in another forum:
In order to remap those locked shortcuts you have to edit following file: vista: c:\users\(username)\appdata\local\risen\configuser .xml xp: c:\documents and settings\(username)\appdata\risen\configuser.xml Your setting will probably be in line 77. Just change "Key_F8=QuickSave_0" to anything you want it to be. For Example "Key_O=QuickSave_0"