What he said, hardcore mode and aiming down sights. There's a bit more armor types in NV and quite a bit more weapons in NV also. But the overall gameplay is basically the same. It is still quite a bit of fun and personally I liked the DC wastland setting better than NV.
As one other said, I prefer the setting of a DC wasteland over the New Vegas wasteland. The games are very similar and very enjoyable. Obviously since you've played FNV, you knkow that the replay value is outstanding. FO3 is no different, very high replay value and a very good buy, especially because its getting to be much older, the price is going down on the GOTY copy, and who dosent like saving money right?:D lol but seriously, it is a very good game and my suggestion is to get a GOTY edition so that you will have all the DLCs and enjoy the game to its max. Cheers!
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