Just started playthrough 2 at level 40. My goal is to go straight up the main quest line, saving as many of the side quests as possible, until playthrough 2.5 or I'm lvl 50. Are there any side quests that disappear or become unavailable due to advancement on the main quest line... or any that you suggest be done for another reason? Thanks.
I played only the story missions for my 2nd playthrough, everything worked out fine. After beating the 2nd playthrough everything hits the level cap of 50, 51, 52, and sometimes level 53. But yea you should be able to do all the side missions afterwards.
Ive just completed borderlands 1 about 2 weeks ago and was going to play frew again shortly and never thought to just do the story missions. But now i will. You forget what the story is until the crappy end lol.