When Crypto-136 is wounded and captured on Earth by the U.S. Army it's up to Crypto-137 to rescue 136. How? By extracting human brains for Furon DNA which they need to survive, of course.
Crypto-137’s first stop is Turnipseed Farm somewhere in the Southern United States and initially it’s thought the cows are the dominant lifeform on Earth. Eventually the police, military, and the mysterious Majestic organization show up. Naturally, humans become your new target.
In the opening level you learn how to read minds with Cortex Scan, throw things around with Psychokinesis, zap people and animals with the Zap-O-Matic gun, and extract DNA from the brain. You also get to pilot the flying saucer to destroy buildings, people, and auto-mobiles.
Destroy All Humans is a remake of the 2005 game with the same title. The game itself reads, “Humans of planet Earth, be advised: while the experience has been upgraded, the content and historical record of the original invasion of the Furons remains a near-identical clone!” The remake is planned to be released for PS4, Xbox One, Stadia, and PC on July 28, 2020.