More the same, but still as good as ever.
Story starts in Africa, Camp Zakara in Republic of Costigar where Dr. Stiles and Angie Thompson are treating patients three years after the events of the first game. This African episode acts as a long tutorial and shortly you'll be travelling to USA in Caduceus hospital at Angeles Bay. Your job now is to treat PGS or Post-GUILT Syndrome. GUILT was the main issue in the first game and it's an artificial infectious disease. In my opinion being a surgeon is already so exotic that you don't need to add any super viruses or space mutants in order to make a good game. Story is told via still images and LOTS of text: sometimes it can take up to 25 minutes just to read an extensive dialog before you can actually play.
Graphics are pretty much exactly the same as before, but still it doesn't feel old or used. Colors are mostly bright and white, just as you would expect from a hospital environment. Music is impressively good and although it loops quite often it still doesn't get too irritating to listen. Sound effects are appropriate and aside from short shouts there is no real voice acting involved.
Gameplay is done with the stylus and you wouldn't want to do it in any other way. Everything works smoothly after you've given yourself enough time to learn the ropes. Trauma Center is essentially a puzzle game, where each operation consists of numerous puzzles you need to solve in order to make progress. This concept still causes much trial and error gameplay especially on a higher difficulty setting. So keep this in mind when considering about making a purchase.
Trauma Center: Under the Knife 2 is a quality game and still quite unique among video games. Unfortunately it's also the definition of "more the same".