Titan quest is a better Diablo II clone with better graphics and lot less mouse clicking.
The constant clicking would hurt my finger in Diablo II. In Titan quest you can just hold down the mouse button and it will keep hitting.
The ability to open a portal to go sell stuff is cool or you could avoid just picking up everything since you will have plenty of money anyway.
I was running the game at 1920x1080 resolution with VSync and AA enabled. The game is very stable. Not a single crash.
You cannot play the game for a short while, save and exit because like Diablo II, each time you start the game, all the enemies respawn. It is a long game. I have been playing it pretty much for 3 full days now.
A simple game that pretty much requires no brains. Just hack and slash fun.
I was playing this game on 64bit Vista.