Harvest Moon with a touch of adventure! A great RPG for the Wii.
Many characters from the first Rune Factory for the DS have returned. Although I've only played the 2nd Rune Factory, I find Rune Factory Frontier a lot more fun to play. Interaction between characters are more interesting and even funny at times, and the voice acting is decent.
The main feature that's new from the first two games are Runeys. These are little elemental sprites that float around that you can eventually catch later on and exchange them to an NPC for special miracles, or you can place them in different areas around town to make things grow faster.