I have rather weak notebook to play games on (well, it's about 4 years old so no surprise). But I did manage to set ME2 video options to be able to play it smoothly, more or less. I had about 10-15 FPS which was playable with no problem.
Now, the moment I started to update my AMD and nVidia PhysX drivers to their latest versions, FPS has dropped to 5-10 - which is unplayable. Unfortunately, I deleted old drivers from Windows backup repositories and didn't remember what drivers they were.
So, I'm screwed up now, probably...
(I don't want to play ME2 in window...)