EFL: Strategy Football (1999)
Enigma Football League: Strategy Football lets you hone your coaching skills as you choose which plays to make in various simulated situations.
Eldevin is a story-driven MMORPG playable in any modern Web broswer via a Java applet where you must help the Kingdom of Eldevin stop Tristan, the Emperor of the Infernal Empire, from conquering the Spheres.
Empire (based on Orson Scott Card novel)
Empire is based on the Orson Scott Card novel about a possible future American Civil War.
Edge of Twilight
Travel through the two parallel realms of Hellayem, each featuring their own powers and perils, and explore the mysteries that pervade the land.
EyeToy: Play 3
EyeToy: Play 3 lets you and three of your friends compete in a variety of minigames, including beach volleyball, bowling, and more.
Evil Twin: Cyprien's Chronicles
The developers of Rayman 2 are up to their usual tricks, this time creating a platformer with a markedly darker tone.