Impossible without a guide or map.
If you don't have a map, get ready to enter 5 rooms that look the same, but only one of them has a block that can be destroyed or is passable, revealing the secret passage you have to take, (and take note this block wont have any hint of its difference what so ever. It'll look just like all repeating block tiles of floor, wall, or ceiling). This will happen through out the whole game and it gets harder and harder.
If you do have a map or a guide with you, you'll know where to go and will get passed the ridiculously hidden passages, and will spend a lot of time collecting upgrades, journeying through eree places and defeating creepy alien like monsters. It'll be fun with a map and guide with you at all times, and a really mean it when I say you don't play it alone because your map/guide beat the game with you.