Genesis version isn't actually that great. C64 version is better.

User Rating: 3.1 | Ghostbusters GEN
I found this game to be very difficult on the C64. Along with busting ghosts around New York you had to manage the company's budget. The more ghosts you successfully caught (not that easy) the more money you got and you could upgrade your equipment and Ecto-1. Like I said, I wasn't very good at it and the game always went very badly once Gozer came to town. The Keymaster and the Gatekeeper would find each other and then that would be 'game over'.

Knowing full well that the Genesis version is completely different, I thought I would give it a go anyway. It's not good. Instead of being a skill-based sort of RPG it's a horrid platformer with poorly designed, absurd levels and ugly characters that look like head-knockers. The managerial aspect is still there but not as fun. And why are the Proton Packs not flying out proton streams? They fire slimy bullets instead. What? That's not what we saw in the movies! It's actually very similar to the Extreme Ghostbusters: Code Ecto-1 game released for the GBA in 2002. It's a rather boring platforming shoot-em-up that makes you feel like a Ghostbuster in no way at all.

I'd actually stick to the C64 version.