| Name | Location | Significance |
| Ubaasi | Saturan Cave Slave | |
| Udarra | Saturan Cave Slave | |
| Ughash gro-Batul | Gnisis Guard and Spearman of the Imperial Legion (wandering NPC) | |
| Ukawei | Ebonheart Healer and Twin Lamps of the Twin Lamps (Argonian Mission) | One of the Twin Lamps anti-slavery movement |
| Ula | Panat Slave | |
| Ulath-Pal | Erabenimsun Camp Ashkan of the Ashlanders (Ashkhan's Yurt) | Plays a role in the Blades quest initiated by Nibani Maesa relating to the Nerevarine Prophecies. Equipped with a unique axe (War Axe of Airan Ammu, Fortify strength 15-30) |
| Ulenea Beloren | Kudanat denizen | Hostile NPC |
| Uleni Heleran | Wolverine Hall Mage and Apprentice of Mages Guild (Mages Guild) | Spells. Spellmaking. Target of a quest given by Angaredhel in Sadrith Mora |
| Ulibabi | Erabenimsun Camp Hunter and Hearthfriend of the Ashlanders (Massarapal's Yurt) | |
| Ulisamsi Saddarnuran | Maar Gan Egg Miner (residence) | |
| Ulmesi Baryon | Vivec Arena Quarter Agent (Hidden Area) | Trainer |
| Ulmiso Maloren | Ghostgate Healer and Initiate of the Temple (Tower of Dawn Lower Level) | Spells. Barters a few potions. |
| Ulms Drathen | Molag Mar Crusader (Waistworks Armiger Stronghold) | Trainer (master of Long Blade) |
| Ulms Saren | Kushtashpi Shrine Mage | Hostile NPC |
| Uloth gra-Ushar | Gnisis Guard and Spearman of the Imperial Legion (Fort Darius) | |
| Ultis Salam | Vivec Arena Quarter Scout (Arena Fighters Quarters) | Trainer |
| Ulumpha gra-Sharob | Gnisis Healer and Spearman of the Imperial Legion (Fort Darius) | Trainer. Barters potions and some reagents. |
| Ulvena Arobar | Punsabanit denizen | Hostile NPC |
| Ulveni Daram | Vivec Redoran Quarter Waistworks Noble (wandering NPC) | |
| Ulves Marvel | Ainat denizen | Hostile NPC |
| Ulvil Llothas | Vos Farmer (wandering NPC) | |
| Ulvon Uleni | Odibaal denizen | Hostile NPC |
| Ulyne Henim | On Vas Island, in Sheogorad | Helps you in a quest given by Percius Mercius in Ald'ruhn. |
| Ulyno Uvirith | Vivec Redoran Quarter Master-at-Arms and Retainer of Great House Redoran (Drillmaster and Scout office) | Trainer |
| Umbacano | Yassu Mine Mage | |
| Umbra | Warrior in hills east of Suran | Wields the powerful magical long sword, Umbra, and gives a quest. |
| Umug gro-Mashnar | Valenvaryon denizen (Umug's Hut) | Hostile NPC |
| Undil | Witchhunter near Dunairi Caverns in Ashlands | |
| Unila Berendas | Rethan Manor commoner (residence) | |
| Unjara | Ules Manor Slave (wandering NPC near the Suran coast) | |
| Uradras Sadalas | Ularradallaku Shrine denizen | Hostile NPC |
| Uram gro-Glorzuf | Maar Gan Warrior (Andus Tradehouse) | |
| Urandile Selandas | Vivec Hlaalu Quarter Commoner (Hlaalu Records) | |
| Uresa Omoril | Ald Daedroth denizen (Right Wing) | Hostile NPC |
| Ureso Drath | Ald'ruhn Enchanter and Novice of the Temple | Enchanter, barters some decent magic weapons, armor and scrolls. |
| Ureval Dralayn | Ald'ruhn Warrior and Hireling of the Great House Redoran (Llethri Manor Private Quarters) | |
| Urfing | Fort Moonmoth trader | Barters a range of weapons, armor and items |
| Urim gro-Bulag | Bal Fell Shrine Warrior and Associate of Mages Guild (Outer shrine) | |
| Urjorad | Ashalmimilkala Shrine body | Dead NPC. The scroll next to his body is the target of a quest given by Lalatia Verian of Ebonheart. |
| Urnel Relas | Beshara Denizen | Hostile NPC. Trainer. |
| Urshamusa Rapli | Ahemmusa Camp Wise Woman and Initiate of the Ashlanders | Gives a quest. |
| Ursine | Nerano Ancestral Tomb body | Dead body |
| Urtisa Romayn | Sadrith Mora Commoner (residence) | |
| Urtiso Faryon | Sadrith Mora Sorcerer and Oathman of Great House Telvanni (residence) | Spells. Spellmaking. |
| Urul gro-Ghorak | Caldera Knight (Ghorak Manor) | |
| Urven Davor | Vivec Foreign Quarter Enforcer and Retainer of the Great House Hlaalu (Black Shalk Cornerclub) | |
| Urvene Arvel | Arvel Manor Noble and Oathman of Great House Hlaalu (East of Dren Plantation) | |
| Uryne Nirith | Balmora Commoner (Hlaalo Manor) | She is located in Hlaalo Manor, which is locked. She can give you a description of Ralen Hlaalo's killer, which will lead you to Thanalen Velas in the Council Club |
| Urzog gro-shadbuk | Orc Warrior (Sheogorad Region SW of Dagon Fel)) | Hostile NPC |
| Urzoth gra-Bargamph | Tel Aruhn Underground Warrior (wandering NPC) | |
| Ushat gra-Gulfim | Hlormaren Denizen | Hostile NPC |
| Ushug gra-Olurba | Agent guarding the ruins in Ashurnibibi | Trainer |
| Utadeck | Gnisis slave (Madach Tradehouse) | |
| Uthrel Sarys | Vivec Redoran Quarter Commoner (Dralor Manor) | |
| Uulernil | Pelagiad Smith (Uulernil's Armorer shop) | Repairs items and barters a large variety of non-magical weapons and armor. |
| Uupse Fyr | Tel Fyr Caretaker (Corprsarium Bowels) | Gives a simple quest. |
| Uvisea Benethran | Mannammu Denizen | Hostile NPC |
| Uvoo Llarem | Ghostgate Monk and Master of the Temple (Temple) | Trainer for Temple members of sufficient rank. Gives quests on behalf of the Temple |
| Uvren Tures | Odai Platform Hlaalu Stronghold (residence) | Trainer |
