| Name | Location | Significance |
| Sadal Doren | Ald Velothi Rogue (wandering NPC ) | |
| Sadela Areth | Tel Mora Sorcerer and Retainer of Great House Telvanni (Upper Tower) | |
| Sader | Ebonheart Warrior and Champion of Imperial Legion (Imperial Commission) | |
| Sakin Sanammasour | Suran Commoner and Clanfriend of the Ashlanders (Tradehouse) | |
| Sakiran | Urshilaku Camp Hunter and Clanholder (Sakiran's Yurt) | |
| Sakulerib | Zainab Camp Herder and Initiate of the Ashlanders (wandering NPC) | |
| Salama Andrethi | Tel Mora Nightblade and Oathman of Great House Telvanni (Tower Services) | Spells. |
| Sal Pudashara | Ashlander Camper (SE of Tel Fyr, SW of Kaushtarari Shrine) | Hostile NPC |
| Salattanat | Erabenimsun Hunter and Brother of the Ashlanders (residence) | |
| Salay Yessur-Disadon | Ashlander south of Halit Mine | Hostile NPC. Trainer. |
| Salen Ravel | Maar Gaan Priest and Novice of the Temple (Shrine) | Spells, Spell-maker, barters potions, reagents and books. |
| Salmat Elarrapal | Ashlander Camper (on island NW of Sadrith Mora) | Hostile NPC |
| Salmus Kaushmamanu | Ashlander Camper (camp north of Hairat-Vassamsi Egg Mine) | Hostile NPC |
| Salora Salobar | Vivec Telvanni Quarter Sorcerer and Retainer of Great House Telvanni (Tower) | Plays a role in a Morag Tong quest. |
| Salvas Areleth | Ald Daedroth denizen (Left Wing) | Hostile NPC |
| Salver Lleran | Vivec Telvanni Quarter Waistworks Sorcerer and Spellwright of Great House Telvanni (Sorcerer's shop) | Spells. Spellmaking. |
| Salyn Sarethi | Ghostgate Buoyant Armiger and Adept of the Temple (Tower of Dusk Lower Level) | Target of a quest given by Frald the White in Ebonheart. The chest in his barracks is also the target of a quest given by Gentleman Jim in Vivec Foreign Quarter Canton. |
| Salyni Nelvayn | Ald'ruhn Assassin (Morag Tong Guild) | Trainer. |
| Samia | Pelagiad Sorcerer (Halfway Tavern) | |
| Samsi Ulannanit | Mamshar-Disamus Camp Ashlander | Hostile NPC |
| Sannit Kil | Ashlander Camper (SE of Erbenimsun Camp) | Hostile NPC |
| Santinti Assarbeberib | Ashlander Camper (NW of Zainab Camp) | Hostile NPC |
| Sanvyn Llethri | Ald'ruhn Great House Redoran member (Llethri Manor Bedrooms) | |
| Saras Orelu | Molag Mar Healer (Temple) | Spells. Barters potions. |
| Saetring | Molag Mar Priest (Waistworks Saetring's Smith) | Repairs, barters basic weapons, armor and smith tools. |
| Sanyon | Assurnabitashpi Shrine denizen | Hostile NPC |
| Saprius Entius | Vivec Arena Cantoon Legion Member (Arena Storage, Canalworks) | |
| Sarayn Sadus | Zaintirari denizen | Hostile NPC. Target of a Morag Tong quest. |
| Sargon Santumatus | Massahanud Camp Barbarian (just SW of Indoranyon Fort) | |
| Sarmosia Vant | Ebonheart Monk, Imperial Chapels | Trainer |
| Sarnir the Clerk | Dagon Fel Savant (End of the World) | |
| Saruse Hloran | Vivec Redoran Quarter Warrior and Lawman of Great House Redoran (Redoran Plaza) | |
| Sarvil Sadus | Ginith Ancestral Tomb Warrior | |
| Sarvur Dadri | Assarnud denizen | Hostile NPC. Has a simple key on him. |
| Saryn Sarothril | Maar Gan Master-at-arms and Oathman of the Great House Redoran (Outpost) | Trainer |
| Sason | Khuul Pilgrim (SE of city, on road near Alen Ancestral Tomb) | Gives a quest |
| Sathas Rivul | Ald Velothi Hunter (wandering NPC near docks) | |
| Sathasa Nerothren | Telvanni Thief (Ashanammu cave in West Gash Region) | The target of a Fighters Guild quest given by Eydis Fire-Eye of Balmora |
| Satheri Rothandus | Vivic St Delyn Commoner (St. Delyn Glassworkers' Hall) | |
| Satyana | Arenim Ancenstral Tomb denizen | Gives a quest. |
| Sauleius Cullian | Ebonheart Enchanter and Novice (Imperial Chapels) | Enchant, barters some weapons, scrolls |
| Savard | Vivec Redoran Quarter Smith and Oathman of Great House Redoran (Smith) | Repair. Barters basic weapons, armor and smith tools. |
| Savesea Mothryon | Sadrith Mora Mage and Lawman of Great House Telvanni (Tel Naga General Quarters) | |
| Savile Imayn | Tel Aruhn Slaver | Sells slaves S'Bakha, Manilian Scerius, Meelras, Ciralinde, Jadier Mannick and Davina. Plays a role in a Blades quest initiated by Nibani Raesa in Urshilaku Camp |
| Savure Uvalor | Pinsun denizen | Hostile NPC, armed with a glass weapon. |
| Scelian Plebo | Wolverine Hall Healer and Novice of the Imperial Cult (Imperial Shrine) | Spells. Barters potions and reagents. |
| Seanwen | Vivec Arena Quarter Waistworks Master-at-Arms (Fighters Training) | Trainer (master of Heavy Armor) |
| Seba Anurnudai | Salit Camp Ashlander | Hostile NPC |
| Sedam Omalen | Ald Velothi Priest and Retainer of the Great House Redoran (Outpost) | Spells, Spellmaking, Barters some potions and reagents |
| Sedrane Arvel | Dren Plantation Noble and Retainer of Great House Hlaalu (East of Plantation) | |
| Sedris Omalen | Maar Gan Master-at-arms and Oathman of the Great House Redoran (Outpost) | |
| Sedyni Veran | Vos Shipmaster | Travel |
| Seen-Rei | Abebaal Mine Slave | |
| Seewul | Suran Slave (Slave Market) | |
| Segunivus Mantedius | Buckmoth Fort Savant and Initiate of the Imperial Cult | Trainer, Barters guides. Can play a role in a quest given by Odral Helvi in Caldera. |
| Seldus Nerendus | Khuul Caravaner (Stilt Strider) | Travel |
| Seliulus Laenius | Nammu Agent | Trainer |
| Selk Muddumummu | Ashlander Camper (SE of Ghostgate, East of Dunirai Caverns) | Hostile NPC |
| Selkirnemus | Molag Mar Trader (Waistworks Pilgrim's Rest) | Barters a few reagents. |
| Sellus Gravius | Seyda Neen Knight Errant of the Imperial Legion (Custom Office) | Tells you of the Emperior's request and how to join Imperial Legion |
| Selmen Relas | Ghostgate Ordinator and Adept of the Temple (Tower of Dawn) | |
| Selvia Famalius | Mannammu Warrior | Hostile NPC |
| Selvil Sarecloth | Stilt Strider merchant in Balmora | |
| Selvura Andrano | Gnaar Mok Pawnbroker and Thug of the Camonna Tong (Nadene Rotheran's Shack) | Barters books. |
| Sen | Ahemmusa Camp Herder and Hearthfriend of the Ashlanders (wandering NPC) | |
| Sendus Sathis | Monk and Initiate of the Temple (in wilderness in wild on small island SW of Dagon Fel) | Target of a Temple quest given by Uvoo Llaren in Ghostgate. |
| Senilius Cadiusus | Nchuleftingth Mage (just to the right of entrance) | Target of a quest given by Edwinna Elbert in Ald'ruhn. |
| Senipu | Urshilaku Camp Herder and Initiate (residence of Ahasour) | |
| Senise Thindo | Tel Aruhn Battlemate and lawman of Great House Telvanni (Tower Living Quarters) | |
| Senyndie | Vivec Arena Quarter Monk (Arena Fighters Quarters) | Trainer (master of Acrobatics). |
| Seras Gavos | Tel Branora Sorcerer and Lawman of Great House Telvanni (Lower Tower) | |
| Serer Andrano | Dren Plantation Noble and Hireling of Great House Hlaalu (wandering NPC near the Suran coast) | |
| Serila Arval | Ald Velothi Commoner (residence) | |
| Serjo Avon Oran | Suran Governor (Oran Manor) | Trainer. Barters thief tools. |
| Sernsi Drelas | Rethan Manor commoner (residence) | |
| Serul Dathren | Vivec Arena Quarter Monk (Hidden Area) | Trainer |
| Seryn Othralen | Vivec Foreign Quarter Lower Waistworks Noble (wandering NPC) | |
| Seryne Relas | Tel Branora Mage (residence) | Trainer (master of Alteration) |
| Sethesi Adas | Shurinbaal denizen | Hostile NPC |
| Sevame Saryon | Dun-Ahhe denizen | Hostile NPC |
| Severa Magia | Ald Sotha denizen | Hostile NPC. Equipped with Daedric Darts and a Daedric Tanto, and several constant effect sanguine items of jewelry. The target of a special duties quest of the Morag Tong. |
| Sevilo Othan | Shulk Egg Mine Poacher | Can be found poaching eggs in the Shulk Egg Mine in Arcadian Island Region. The target of a Fighters' Guild Quest |
| Sevisa Teran | Vivec St. Olms Quarter Canalworks Pauper (wandering NPC) | |
| Sevyni Saryon | Vivec Foreign Quarter Lower Waistworks Savant (wandering NPC) | Trainer. Barters books and maps. |
| Shaba | Minabi denizen | Slave |
| Shabinbael | Urshilaku Camp Hunter and Brother (wandering NPC) | |
| Shadbak gra-Burbug | Pelagiad Fort Smith | Repairs. Barters some smith tools and weapons and armor. Plays a role in a quest given by Sugar-Lips Habasi in Balmora. |
| Shagar gra-Snagarz | Vivec St. Olms Quarter Plaza Bard and House Cousin of Great House Hlaalu (Yngling Manor) | |
| Shagdub gra-Murz | Tel Aruhn Warrior (wandering NPC) | |
| Shakh gro-Durga | Assurdirapal Shrine denizen | Hostile NPC. Trainer. |
| Shali Assannabalit | Ashlander Camper (SE of Ghostgate, SE of Dunirai Caverns) | Hostile NPC |
| Shallath-Piremus | Urshilaku Camp Hunter and Initiate (wandering NPC) | |
| Shamar gro-Ogar | Orc Barbarian near Ramimilk Shrine | |
| Shamob gro-Shatub | Dushariran Shrine agent | Trainer |
| Shanat Kaushminipu | Aharasaplit Camp Archer (SW of Dagon Fel) | |
| Shanit Ashar-Don | Ashlander Camper (camp north of Hairat-Vassamsi Egg Mine) | Hostile NPC |
| Shannat Pansami | Balmora Monk (Morag Tong Guildhouse) | Trainer |
| Shanud Ududnabia | Gnisis egg miner (Egg Mine) | |
| Shara | Urshilaku Camp Hunter and Hearthfriend (Shara's Yurt) | |
| Shara Atinsabia | Ashlander Camper in Grazelands Elanius Camp (SE of Zainab Camp) | Hostile NPC |
| Shardie | Buckmoth Fort Crusader and Agent of the Imperial Legion (in courtyard) | Trainer (master of Block) |
| Shargam gro-Shagdulg | Balmora Commoner (wandering NPC) | |
| Shargon Odin-Ahhe | Dark Elf in wilderness west of Gnisis | Hostile NPC |
| Sharkub gro-Khashnar | Gnisis Drillmaster and Agent of the Imperial Legion (Fort Darius) | Trainer |
| Sharn gra-Muzgob | Balmora mage (Mages Guild) | Has a bet with Galbedir about becoming a journeyman. Insists not a Necromancer, barters potions, trains and sells spells. Will give you a quest you need to solve in order to advance the game's main quest. |
| Sharog gra-Ulfish | Hlormaren Barbarian | Prison Guard |
| Shat gro-Shazog | Warrior (outside Dushariran Shrine) | |
| Shatalg | Dren Plantation Slave (East of Plantation) | |
| Shazgob gra-Luzgan | Ebonheart Trader (East Empire Company Hall) | |
| Shelur gra-Yargul | Zergonipal Shrine denizen | Hostile NPC |
| Shenk | Caldera Publican (Shenk's Shovel) | Barters some potions and ingredients |
| Shilipuran Zama-Rasour | Maar Gan Commoner (wandering NPC) | |
| Shimsun | Urshilaku Camp Hunter and Guide (residence) | |
| Shin Assemmus | Ashlander Camper (just east of Falensarano Fort, Grazelands) | Hostile NPC |
| Shinammu Radansour | Dark Elf in wilderness NE of Gnisis | Hostile NPC |
| Shipal Zansatanit | Ashlander Camper (NW of Yansirramus Shrine) | Hostile NPC. |
| Shirerib Ashi-Iddan | Ashlander Camper (NW of Zainab Camp) | Hostile NPC |
| Shishi Yanumibaal | Ashlander Camper (west of Ahemmusa Camp) | Hostile NPC |
| Shivani | Hlormaren Slave | |
| Sholani | Sha-Adnius denizen | Slave |
| Shotherra | Khuul Assassin (Thongar's Tradehouse) | Has one of the Sanguine items needed by the Morag Tong. |
| Shulki Ashunbabi | Gnisis Trader (outside Temple) | Barters miscellaneous items and arrows. |
| Shullay Malman-Ammu | Ashlander Camper (just south of Falensarano Fort, Grazelands) | Hostile NPC |
| Shullay Vabdas | Gnisis Egg Miner (residence just west of town) | |
| Shura gro-Urgak | Kaushtarari Shrine denizen | Hostile NPC |
| Shurkul gro-Sharga | Hla Oad Pauper (residence) | |
| Shuzug gro-Bug | Tel Aruhn Warrior (wandering NPC) | |
| Sifknir | Habinbaes denizen | Hostile NPC |
| Silius Fulcinius | Vivec Telvanni Quarter Agent and Retainer of Great House Telvanni (Tower) | |
| Siltalaure | Ebonheart Rogue and Protector of the Fighters Guild (East Empire Company | |
| Simine Fralinie | Vivec Foreign Quarter Bookseller (Canalworks shop) | Barters books. The back door to his ship leads to a Thieves Guild office. |
| Sinia | Maar Gaan (Shrine) | |
| Sinise Thindo | Tel Aruhn guard (General Quarters) | Target of a Redoran quest given by Neloth in Tel Naga. Equipped with an Ebony shield and magic jewelry. |
| Sinnammu Mirpal | Ahemmusa Camp Wise Woman (Wise Woman's Hut) | Spellmaking. Barters basic potions and reagents. Gives a quest that's part of a Blades quest initiated by Nibani Maesa of Urshilaku Camp. |
| Sirialius Catanius | Zanabi Denizen | This hostile NPC will attack you on sight |
| Sirilonwe | Vivec Foreign Quarter Mage (Mages Guild) | Spells. She has a book that is the target of a quest given by Edwinna Elbert in Ald'ruhn. |
| Sinyaramen | Sadrith Mora High Elf (Gateway Inn) | Target of an Aundae vampire quest. |
| Siri | Druscashti Quarra Clan Vampire (Lower Level) | Equipped in full ebony armor. |
| Sirollus Saccus | Ebonheart Smith and Champion of Imperial Legion (Hawkmoth Legion Garrison) | Repair. Barter some weapons and armor and tools (including Sirolus Saccus' Hammer) |
| Sittar | Barbarian on Ship Grytewake, South of Hla Oad | |
| Sjarnfid | Punabi Cave Barbarian | Hostile NPC |
| Sjoring Hard-heart | Vivec Foreign Quarter Guildmaster of the Fighters Guild (Fighters Guild) | Gives high level Fighters Guild Quests. The target of quests given by Percius Mercius in Ald'ruhn and Gentleman Jim Stacey in Vivec Foreign Quarter. |
| Sjorvar Horse-mouth | Master-at-arms and apprentice of the Blades (resdence in West Gash, NE of Gnaar Mok, SW of Ald'ruh) | Trainer |
| Skink-in-Tree's-Shade | Wolverine Hall Mage (Mages Guild) | Trainer (master Speechcraft). Barters books and guides to mages of sufficient rank. Gives quests on behalf of Mages Guild, and is the target of a quest given by Edwinna Elbert in Ald'ruhn. |
| Sloomalah | Ald Daedroth Witch (Outer Shrine) | Hostile NPC |
| Smart-snake | Hlormaren Slave | |
| Smokeskin-Killer | Tel Vos Warrior and Retatiner of Great House Telvanni (Central Tower) | |
| Smokey Morth | Vos Sorcerer (Varo Tradehouse) | |
| Snadir | Zainsipilu Cave denizen | Hostile NPC slaver, has the Zainsipilu slave key |
| Snaglak gro-Yak | Valenvaryon denizen (Umug's Hut) | Hostile NPC |
| Snakha gro-Marob | Gnisis Warrior and Spearman of the Imperial Legion (Madach Tradehouse) | |
| Snat gro-Ushug | Vivec Arena Quarter Commoner (Arena Pitt) | |
| Snorri | Suran non-descript NPC (House of Earthly Delights) | |
| Snowy Granius | Necromancer that blocks the bridge north of Fort Moonmoth | |
| Socucius Ergalla | Seyda Neen Custom Official | Trainer. NPC that assists in character creation |
| Sodrara Andalas | Gnaar Mok Savant and Thug of the Camonna Tong (Nadene Rotheran's Shack) | Trainer, Barters books. |
| Sodres Nerethi | Marandas denizen (Upper level) | Hostile NPC |
| Sold Fine-Hair | Dagon Fel Smuggler (End of the World) | |
| Solea Nuccusius | Fort Moonmoth Guard | Spells |
| Somutis Vunnis | Fort Moonmoth Priest | Spells, Spellmaking, Barter some potions and reagents |
| Sondaale of Shimmerene | Telasero Fort Scholar (lower level) | Target of a quest given by Hrundi in Sadrith Mora. |
| Sondryn Irathi | Wolverine Hall Scout and Apprentice of Fighters Guild (Fighters Guild) | Trainer. |
| Sonummu Zabamat | Zainab Camp Wise Woman (Wise Woman Yurt) | Spells. Barters a few basic potions. Plays a role in a Blades quest initiated by Nibani Raesa in Urshilaku Camp |
| Sor | Panat denizen | Hostile NPC |
| Sorcalin | Yassu Mine Nightblade | |
| Sorkvild the Raven | Dagon Fel Necromancer (Sorkvild's Tower) | Hostile NPC. Target of a quest given by Radd Hard-Heart in Fort Moonmoth |
| Sorosi Radobar | Vivec Redoran Quarter Publican (Flowers of Gold) | Barters potions and reagents. |
| Sortis Rahryon | Molag Mar Monk and Layman of the Temple (Temple) | |
| Sosia Caristiana | Caldera Healer (on road NW of Caldera) | She plays a role in a quest initiated by Hlormar Wine-Sot, who is also on the road NW of Caldera, closer to the city. |
| Sottilde | Balmora Pawnbroker (South Wall Cornerclub) | Sells a couple of weapons and tools. Thieves Guild. You have to take a codebook off her in a Fighters Guild quest for Eydis Fire-Eye |
| Sovali Uvayn | Vivec Hlaalu Quarter Thief and Oathman of Great House Redoran (Elven Nations Cornerclub) | Trainer. Barters thief tools. |
| Sovisa Adas | Vivec St. Olms Underworks (Assernaerairan Shrine) | |
| Sovor Trandel | Balmora Savant (Council Club) | Trainer. A member of the Cammona Tong, Thanelen is the target of a quest from Larrius Varo of Fort Moonmoth. He also has a key to Nerano Manor, which you can bribe from him or pickpocket, which will net you a nice reward from Sugar-lips Habasi |
| S'Radirr | Pulk denizen | Hostile NPC |
| S'Rava | Sadrith Mora Slave (Gateway Inn) | |
| S'Raverr | Minabi denizen | Slave |
| S'Renji | Hlormaren Slave | |
| Staada` | Golden Saint Daedra (island NW of Dagon Fel) | Target of a quest given by Azura's shrine. |
| Star | Vivec St. Olms Quarter Plaza Spellsword and House Cousin of Great House Hlaalu (Yngling Manor) | |
| Stargel | Balmora Commoner (wandering NPC) | |
| Stenet | Molag Mar Commoner (St. Veloth's Hostel) | |
| Stentus Tullius | Tel Aruhn Trader (wandering NPC) | Target of a quest given by Marsius Tullius near Erabenimsun Camp. |
| Sterdecan | Farmer (NE of Dren and Arven Plantation) | Plays a role in a quest given by Ilmeni Dren in Vivec St. Delyn. |
| Sticey | Kushtashpi Shrine denizen | Hostile NPC |
| Stlennius Vibato | Caldera Mine ebony miner (Mining Company Office) | |
| Stlubo Otiustiris | Almurbalarammi Shrine denizen | Hostile NPC. Trainer. |
| Stream-Murk | Molag Mar Slave (on top of Canton) | |
| Strillian Macro | Gnisis Spellsword and Trooper of the Imperial Legion (barracks) | |
| Subenend Urshummaramus | Ashlander Camper (Sobitbael Camp) | Hostile NPC. Trainer. |
| Sugar-Lips Habasi | Balmora Thief (South Wall Cornerclub) | Trainer, Barters thieves tools. Welcomes new members to Thieves Guild. The target of a quest given by Sjoring Hard-Heart in Vivec Foreign Quarter. |
| Sulen Sarandas | Sanabi denizen | Hostile NPC |
| Sulesa | Nammu Denizen | Hostile NPC |
| Sulis Rendas | Andasreth Fort denizen (roof) | Hostile NPC |
| Sul-Matuul | Urshilaku Camp Ashkan | Gives you a quest and plays a role in Blades quests. |
| Surane Leoriane | Caldera Mage and Journeyman of the Blades (residence) | Trainer |
| Sur Surishipi | Ashlander Camper (just south of Vos) | Hostile NPC |
| Surus Velvus | Arkngthand Denizen | This hostile NPC will attack you on sight |
| Suryn Athones | Vivec Temple Quarter Ordinator and Curate of the Temple (Hall of Justice) | Target of a quest given by Frald the White in Ebonheart. |
| Suvryn Doves | Dren Plantation Thief (Doves' Shack) | Trainer. Plays a role in a quest given by Lorbumol gro-Aglakh in the Fighters Guild in the Foreign Quarter in Vivec. |
| Svadstar | Khuul Commoner (wandering NPC) | |
| S'Vandra | Hlormaren slave (on roof) | |
| Svog | Bal Ur Barbarian | Hostile NPC |
| Syloria Siruliulus | Fort Buckmoth Trader and Adept of the Imperial Cult | Barters some basic weapons, armor, potions, books and miscellaneous items |
| Synette Jeline | Woman in wilderness near crossroad north of Gnisis on the way to Ald Veloth | Gives a quest |
| Synnolian Tunifus | Ebonheart, Imperial Chapels | Trainer. Barters some potions and gives quests on behalf of the Imperial Cult. |
