| Name | Location | Significance |
| Earmil | Assurnabitashpi Shrine denizen | Hostile NPC, who has one of the Sanguine items needed by the Morag Tong (Ring of Sanguine wisdom) |
| Edd "Fast Eddie" Theman | Balmora Citizen (residence, just above Itan's house) | Plays a role in several Telvanni quests. He is required in order for you to advance in House Telvanni. |
| Edras Oril | Fields of Kummu traveler (NE of the shrine and Thoronor) | The target of a quest given by Thoronor. |
| Edryno Arethi | Vivec Hlaalu Quarter Waistworks business of Great House Hlaalu (residence) | Trainer. Gives quests for Great House Hlaalu. |
| Edwinna Elbert | Ald'ruhn Mage and Conjurer of the Mages Guild (Mages Guild) | Spells, Spellmaking. Gives quests for the Mages Guild. |
| Eigma | Ald Daedroth denizen (Inner Shrine) | Hostile NPC. |
| Eindel | Ald'ruhn Archer and Hireling of Great House Redoran (Llethri Manor Entrance) | Stores his Darts of Judgement on his bed in the Guard Quarters, which are the target of a Thieves Guild quest given by Aengoth the Jeweler in Ald'ruhn. |
| Eiruki Hearth-Healer | Ebonheart Barbarian and Trooper of the Imperial Legion (Skyrim Mission) | |
| Ekapi | Panat denizen | Slave |
| Ekkhi | Ebonheart Battlemage and Champion of Imperial Legion (Imperial Guard Garrison) | |
| Elam Andas | Vivec Temple Quarter Crusader and Curate of the Temple (Office of the Watch) | Gives a quest |
| Elante | Ibar-Dad denizen | Hostile NPC |
| Eldafire | Seyda Neen Commoner (wandering NPC) | |
| Eldil Bradyn | Buckmoth Fort Prisoner | |
| Eldrar Fathyrom | Vivec Telvanni Quarter Merchant and Oathman of Great House Telvanni (Cantoon wandering NPC) | |
| Eldrasea Helas | Punabi Cave Mage | Hostile NPC |
| Eldrilu Dalen | Vos Priest and Novice of the Temple (Chapel) | Spells. Spellmaking. Barters potions, reagents and books. |
| Eleedal-Lei | Abebaal Mine Slave | Target of a Telvanni quest given by Felisa Ulessen in Sadrith Mora. |
| Elegal | Sadrith Mora Trader (Outdoors, near tower) | Barters basic weapons, items, potions and miscellaneous items. |
| Elegnan | Tel Mora Clothier (residence) | Barters clothes |
| Elenwen | Dun-Ahhe denizen | Hostile NPC |
| Elethus Tobor | Vivec St. Delyn Plaza Rogue (Potter's Hall) | |
| Elibael Puntumisum | Ashlander Camper (SE of Molag Mar) | Hostile NPC |
| Elitlaya Assonirishpal | Ashlander Camper (NW of Yansirramus Shrine) | Hostile NPC |
| El-Lurasha | Vivec Telvanni Quarter Slave (Cantoon, behind locked door) | |
| Elmera Verethi | Vivic St Delyn Commoner (St. Delyn Glassworkers' Hall) | |
| Elms Llervu | Vivec Redoran Quarter Waistworks Savant and Kinsman of Great House Redoran (wandering NPC) | Trainer |
| Elmussa Damori | Caldera Thief (residence) | |
| Elo Arethan | Vivec Hlaalu Quarter Waistworks Savant and Retainer of Great House Hlaalu (wandering NPC) | Trainer. Barters books. |
| Eloe | Galom Daeus Vampire | Berne Clan Vampire |
| Elone | Seyda Neen Scout and Journeyman of the Blades (Arille's Tradehouse) | Trainer |
| Eloroth | Vivec Hlaalu Quarter Waistworks Monk and Lawman of the Great House Hlaalu (wandering NPC) | |
| Elphiron | Tel Mora Warrior and Hireling of Great House Telvanni (Upper Tower) | |
| Elumabi Maliiran | Ashlander Camper (south of Daedra ruins of Dushariran) | Hostile NPC |
| Elvas Savel | Molag Mar Drillmaster (Redoran Stronghold) | Trainer |
| Elvasea Thalas | Ghostgate Scout and Oathman of Great House Redoran (Tower of Dusk Lower Level) | |
| Elvil Vidrom | Suran Commoner (wandering NPC) | Target of a quest given by Tuls Valen in Ald'ruhn. |
| Elynea Norvayn | Caldera Mine Warrior (Mining Company Office) | |
| Elynu Saren | Suran Priest and Novice of the Temple (Apothecary) | Spells. Spellmaking. Barters books and reagents |
| Emelia Duronia | Caldera Guild Guide and Journeyman of the Mages Guild (Mages Guild) | Travel |
| Emul-Ran | Ashlander Camper (just north of Vos) | Has a pack Guor, and is the target of a quest given by Athanden Girith in Tel Vos. |
| Emusette Bracques | Tel Aruhn Spellsword and Journeyman of the Mages Guild (Plot and Plaster) | Trainer. Gives a reward for completing the quest initiated by Maurrie Aurmine near Pelagiad. |
| Ena | Mannammu Warrior | Hostile NPC |
| Enar Dralor | Ghostgate Buoyant Armiger and Disciple of the Temple (Tower of Dusk Lower Level) | |
| Endar Drenim | Sadrith Mora Sorcerer and Spellwright of Great House Telvanni (Tel Naga Upper Tower) | |
| Endase Avel | Tel Aruhn Mage and Wizard of Great House Telvanni (Upper Tower) | |
| Endring | Tel Branora Enforcer and Hireling of Great House Telvanni (on hill west of town) | Target of a quest given by Mollimo of Cloudrest in Tel Branora |
| Endris Dilmyn | Khuul Commoner (residence) | |
| Endroni Dalas | Ald Daedroth Witch (Right Wing) | Hostile NPC |
| Endryn Llethan | Vivec Temple Quarter Monk and Master of the Temple (High Fane) | Trainer. Gives quests for the Temple. |
| Endul Rothandus | Vivec Telvanni Quarter Waistworks Pauper (wandering NPC) | |
| Engaer | Sadrith Mora Archmage and Councillor of Great House Telvanni (Tel Naga Upper Tower) | Target of a Fighters Guild quest given by Hrundi in Sadrith Mora. |
| Enjine | Shurinbaal denizen | Hostile NPC. Target of a Redoran quest given by Athyn Sarethi in Ald'ruhn. |
| Ennah | Tel Branora Sharpshooter and Lawman of Great House Telvanni (wandering NPC) | |
| Ennbjof | Vivec Telvanni Quarter Waistworks sailor (The Lizard's Head) | If you give him a bottle of Mazte he'll tell you where the enchanted axe, Stormkiss was buried. |
| Eno Hlaalu | Vivec Arena Quarter Assassin (Hidden Area) | Can initiate you into the Morag Tong, and gives quests on behalf of the Morag Tong. |
| Eponis Vinipter | Shurinbaal denizen | Hostile NPC |
| Eraamion | Caldera Nightblade and Journeyman of the Mages Guild (Mages Guild) | Spells |
| Eradan | Addadshashanammu Shrine denizen | Hostile NPC |
| Eralane Hledas | Vivec St. Olms Canal (North-One) | |
| Eraldil | Vivec Hlaalu Quarter Waistworks Morag Tong member (wandering NPC) | |
| Erene Llenim | Seyda Neen Commoner (wandering NPC) | |
| Erer Darothril | Sadrith Mora Mage (Dirty Muriel's Cornerclub) | Trainer (master of Illusion). Spells. Spellmaking. |
| Ereven Velas | Rotheran Denizen (Arena) | Hostile NPC |
| Ergnir | Ald'ruhn Smith and Apprentice of the Fighters Guild (Fighters Guild) | Repair. Barters a large variety of armor, weapons and smith tools. |
| Erik | Ebonheart Apothecary (Imperial Chapels) | Trainer. Barters potions. Can iniitate you into the Imperial Cult |
| Eris Telas | Vivec Temple Quarter Apothecary and Acolyte of the Temple (High Fane) | Barters large selection of potions and some reagents. |
| Erissare | Aharnabi denizen | Hostile NPC |
| Erivase Drinith | Vivec Hlaalu Quarter Pilgrim (Hlaalu Temple) | |
| Erla | Fort Moonmoth smith | Repair, barters armor and weapons |
| Ernand Thierry | Caldera Alchemist and Journeyman of the Mages Guild (Mages Guild) | Barters a large variety of potions |
| Ernil Omoran | Dead Body south of Caldera | He has as a note and some other items from Tsiya. Take the note and the pipe to Tsiya in Balmora for a reward. |
| Erns Maren | Ashalmawia Shrine Battlemage | Hostile NPC |
| Ernse Llervu | Vivec Delyn Monk (Abbey of St. Delyn the Wise) | Trainer |
| Erradan | Shishara denizen | Hostile NPC |
| Erranil | Ald'ruhn Guild Guide and Apprentice of the Mages Guild (Mages Guild) | Travel |
| Ertius Fulbenus | Gnisis Warrior and Spearman of Imperial Legion (Madach Tradehouse) | |
| Erundil | Indoranyon Fort denizen | Has a Sanguine item needed by the Morag Tong. |
| Erur-Dan | Cavern of Incarnate Failed Incarnate | Gives a spear and cuirass. |
| Erval | Pelagiad Commoner (resdence) | |
| Ervas Aradil | Vivic Temple Quarter Warrior (Ministry of Truth Prison) | |
| Ervesa Romandas | Molag Mar Novice of the Temple (Waistworks Armiger Stronghold) | |
| Ervis Ules | Ginith Ancestral Tomb Mage | |
| Ervona Barys | Ebonheart Battlemage and Knight Bachelor of Imperial Legion (Hawkmoth Legion Garrison) | Spells |
| Ervyna Hlervu | Tel Branora Hunter (residence) | |
| Ery | Sadrith Mora Publican (Gateway Inn) | Barters basic pub potions and reagents. |
| Esar-Don Dunsamsi | Tel Vos Scout and Clanfriend of the Ashlanders (on boardwalk between Central Tower and Barracks) | Trainer |
| Esdrufus Harsinia | Ashinibi denizen | Hostile NPC. Trainer. |
| Esib-Nummu Assunadadnud | Gnisis Pilgrim and Layman of the Temple (Temple) | |
| Estinan | Tel Branora Enforcer and Retainer of Great House Telvanni (on hill west of town) | Target of a quest given by Mollimo of Cloudrest in Tel Branora |
| Estirdalin | Balmora mage (Mages Build) | Trainer. Spells, spell-making. |
| Estoril | Ald'ruhn Thief (The Rat in the Pot) | Spells. |
| Ethal Seloth | Vivec Telvanni Quarter Sorcerer and Oathman of Great House Telvanni (Temporary Housing) | Target of a Morag Tong quest. |
| Ethasi Rilvayn | Balmora Nightblade (Morag Tong Guildhouse) | Spells (for Morag Tong members only). Gives quest for the Morag Tong. |
| Ethes Evos | Ald'ruhn Commoner (Arobar Manor Entrance) | |
| Ethys Savil | Vivec Foreign Quarter Nightblade and Hireling of the Great House Hlaalu (Black Shalk Cornerclub) | |
| Eutei | Saturan Cave denizen | Slave |
| Evesa Omalas | Holamayan Pilgrim | |
| Evilu Indrano | Shushan denizen | Hostile NPC who has the Shushan slave key and a unique book that identifies the game's hand-to-hand master |
| Evos Goran | Tel Branora Commoner (residence) | |
| Eydis Fire-Eye | Balmora Fighter Guild Stewart (Fighters Guild) | Trainer. Potential target of a Fighters Guild quest given by Percius Mercius in Ald'ruhn. Target of a Thieves Guild quest given by Gentleman Jim Stacey in Vivec Foreign Quarter. Gives quests on behalf of the Fighters Guild. |
