they are nowhere near similar in any game mechanics (perhaps the fps perspective, but thats about all).
FO3 is an exploration rpg, its great for that (altho slightly copy/paste feel untill you come to the dlc packs). A great game in its own right, and while I still prefer the fallouts of old I do not hesitate to call it a darn good game.
Borderlands is a shooter... sure you do have certain stats that control sway of your gun, and overall dmg... But it is a shooter, built to be humorous, fun and co-op.
It is sort of an FPS/Lootwh*ring game and the skills you unluck pretty much just alters weapons, and ammoloadouts (and the one special skill each class has).
But it is an amazing game if you like Co-OP shooters, it is dumb fun, and the game knows it itself and runs with it ^^ A cool artstyle, good sound, fun guns to use, and always hunting for better ones is really fun...
But no they are not similar at all... if anything I would say Borderlands has a great deal in common with Diablo, with townhubs to buy/sell items, and get missions, and the great wild outside, guns blazing, wisecracking, and bad attitude ^^
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