Visually my mind go blown away with the levianth boss from dead space , god that looked real to me , especially the first time i saw it :o (the final boss was a joke) I enjoyed R2 bosses though .
Fallout 3 - when I first encountered Super Mutants and barely won that with the skin of my teeth at a drive in. Later, getting ambused by a whole block of them in DC hiding in a small bathroom playing "duck and cover" taking them out one by one. The longest battle I've ever had in Fallout 3 so I would consider those "bosses" lol
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