I can play Fallout 3 and New Vegas just fine on Windows 8.1 for hours at a time with over a hundred mods on both. Are you sure the "quad-core fix" (I think this is what you mean by windows 8 fix, if not it will most likely solve your problem) ini saved and was not overwritten? Every time the auto graphics detect kicks in, it creates a new ini. So if you changed something to trigger the auto-detect, it might be gone. If it is there, try disabling all mods and try enabling them one at a time, you might have a conflict or something.
Also, if you installed texture packs you may be hitting a ram limitation wall as Fallout 3 only uses 3GB of ram by default. In that case, look on the nexus for the Fallout 3 4GB mod, which should help significantly.
At any rate, yes, it can be done. Just keep at it. Reinstall and apply the quad-core fix to the ini and nothing else, if all else fails. That should get it playable. Though Fallout 3 is notorious for crashing, you shouldn't crash that often.
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