Medium textures, shadows and ambient occlusion, the rest on high. I have a very similar PC and have a constant 60FPS with these settings, no matter what.
Any time you are unsure you can run a game just go here.
http://www.systemrequirementslab.com/cyri
They are normally pretty well updated (1 or 2 days after the specs are released at most) and you can either check the requirements or let your components be scanned and you'll be told whether it runs (in theory) or not. Sometimes even if it fails you can still run a game, but normally at low settings and crap performance.
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