Most game franchises coast along for years after the spark of passion has gone out of them. Too many well-known game series are simply the same game, repeated in different environments, with small changes to gameplay. When Resident Evil 4 hit the scene in 2005, however, Capcom made it clear that they were intent on avoiding the same trap. A radical reimagining of the Resident Evil gameplay, RE4 eliminated almost all of the off-putting aspects of the previous games in the series and delivered one of the most polished gaming experiences of the last generation of consoles. The game was an easy choice for GameSpot's Game of the Year for 2005.
In Resident Evil 4, you take on the role of Leon S. Kennedy, a government agent who previously appeared in Resident Evil 2. Tasked to rescue the President's daughter, who's been kidnapped by mysterious villains, you find yourself chasing leads in the backcountry of Spain, where a sinister threat arises, not just against a single kidnapped girl, but against the entire world. Although the Umbrella Corporation is a thing of the past, as are the zombies that infested the previous games, you'll still have plenty of people in your way here.
In GameSpot's guide to Resident Evil 4, you'll find some general strategies to help you out, as well as a complete walkthrough for the game, complete with video coverage of all of the major boss fights. In addition, the unlockable features here are all covered, including the secret weapons and the two major additional gameplay modes: Assignment Ada and the incredibly fun Mercenaries.
Since this guide was originally written for the GameCube version of the game, the Separate Ways content is not covered. Note that most of the mentions of the controls are also based on the GameCube version, so you may need to adapt a bit if you're playing on the Playstation 2 or the Wii. For the most part, though, the content should still be applicable. Enjoy!