Before you can open up OG as a mission-giving character, youll have to pick him up as he walks out of jail. As soon as he hits the bricks, though, he wants to get right back into the gangsta life, and asks CJ to help him kill someone who disrespected him in prison.
When you reach the marker that leads you to the targets house, hell hop out onto a bike, forcing you to give chase. Despite Locs best effort, he wont be able to kill the guy while youre riding around, so youll have to follow the mark until he gets off his bike. (And its going to be a looong ride, so keep the guy in front of you and watch his tire tracks to get an idea of where he went if you lose sight of him.) When he finally does de-bike, hell wander into a group of comrades, so take them out with extreme prejudice.
OG wont give you missions just yet, though; youll have to drop him off at his job before that occurs. If you got wanted stars during the chase, itll be difficult to get all the way to the restaurant without getting arrested, so you may want to check your map for a Pay N Spray before heading out.
Running Dog is one of the simplest missions in the game! Just drive Big Smoke to the "meet," then, after the cutscenes over, chase down and kill the marijuana dealer.
Wrong Side of the Tracks
This is another simple mission, in theory, although it can be difficult. After you escort Big Smoke to the marker, youll have to hop onto a Sanchez and chase a train thats loaded up with rival gangstas. Smoke will fire away as you drive, so long as you can stay near the front of the train, he'll automatically lock onto one of the gang members and start plugging away, but you'll have to keep him in position for a while before each gang member dies, as they have a ridiculous amount of health. Also note that Smoke aims at the rearmost banger first, then switches to the guy in front of him, and so on; thus, you should keep a little bit behind the train's engine car to prevent the gang members that he's not shooting at from having an easy shot at you.
The train is about as fast as your bike - faster when youre going uphill - so youll have to avoid accidents and crashes if you want to take out all four of the foes. You may notice jumps on either side of the train tracks on occasion; if you can run your bike off of one of these and land on the train itself, you can shoot away at the gang members yourself, but you may leave Smoke a ways behind if you do so.
Eventually youll take them all out, though, although its likely to take some time, so enjoy your little trip through the backcountry before escorting Smoke back home.
The last two missions cant quite prepare you for Just Business, a sprawling two-parter that will probably take you a couple of dry runs before you succeed. Be sure to save your game before attempting it, if you dont want to lose all of your weapons when you get processed through the hospital!
The first segment here sees CJ and Smoke fighting their way through a horde of Russians. Why? Were only left to wonder; the Russkies dont really figure into the rest of the games plot. Anyway, youre going to be in a ton of trouble if you dont have a couple hundred rounds for your SMG; if you do, though, you can just cycle your locks to clear out most of the first room. Quickly scoop up any cash or ammo on the floor, and be certain to grab the body armor from the rear of the room before meeting up with Smoke. Youll have to make your way through another gauntlet outside, but youll get a health refill after you do so, so stand up and take them down any way you can.
The second part is by far the harder, as it sees CJ hop on the back of a motorcycle, firing away at Russians as Smoke attempts to escape through the crowded city streets. The Russians will pursue you in cars and motorcycles, as well as in a car-transport truck. You cant hurt the truck, which is the source of most of the scripted events during the chase, so focus on the motorcycles first. Both the drivers and the passengers of the motorcycles will fire at you, so pick them off (youve got unlimited ammo) before moving on to the cars. The Russians in the passenger side seat of the cars will shoot at you, as well, so youll need to shoot them (either through the side or through the windshield) to eliminate that threat.
Its a long, long chase, so youll have to keep your finger on the trigger if you want to survive. Youll know that youre almost near the end when you jump over the exploding truck. Like we said, though, itll likely take a few runs before you actually beat this mission, so dont feel too discouraged if you happen to die.